Watch the hilarious trailer for The Sisters Brothers

The Sisters Brothers is an upcoming western dark comedy directed by Jacques Audiard from a screenplay he co-wrote with Thomas Bidegain based on the novel of the same name by Patrick deWitt. The film will star John C. Reilly and Joaquin Phoenix as the two notorious assassin brothers Eli and Charlie Sisters.

The story follows Eli and Charlie Sisters, two hitmen brothers on the trail of a prospector who has stolen from their boss.

The film stars John C. Reilly as Eli Sisters; Joaquin Phoenix as Charlie Sisters; Jake Gyllenhaal as Morris, the prospector; Riz Ahmed as Hermann Kermit Warm, the chemist; Rutger Hauer as Commodore; and Carol Kane as Mrs. Sisters.